CryoSol-World (CryoSol) is a leading developer of sample preparation technology for cryo-electron microscopy. CryoSol was founded in March 2018 by scientists and entrepreneurs with a track record in the field of cryo-EM and originates from research performed at Maastricht University, the Netherlands. Our VitroJet technology has been invented by the team responsible for the development of its predecessor, the Vitrobot, currently the standard in cryo-sample preparation equipment worldwide.
CryoSol aims to become a global technology leader in sample preparation technology for cryo-EM single particle analysis, cryo-electron tomography, cell biology, soft matter research and liquid phase electron microscopy, enabling scientists, researchers and engineers in their quest to vitrify their samples of interest, allowing high quality imaging and reconstruction.
Cryo-electron microscopy (cryo-EM) plays a key role in unraveling the three-dimensional structure of macromolecules and their cellular functions. This knowledge contributes to developing new medicines and treatments for diseases.
Cryo-electron microscopy (cryo-EM) plays a key role in unraveling the three-dimensional structure of macromolecules and their cellular functions. This knowledge contributes to developing new medicines and treatments for diseases. Vitrification of biological materials is required to preserve the biological samples in their native state. Optimization of the sample preparation process greatly contributes to workflow effectiveness and efficiency. Cryo-EM will shift from ‘high content’-technology to ‘high throughput’-solution, in which sample preparation is the key enabling technology. CryoSol is dedicated to providing high-end sample preparation solutions.
History of CryoSol-World
CryoSol-World is founded on research executed at Maastricht University, dating back to the early 90’s of the previous century. In close collaboration between Dr. Peter Frederik of the cryo-mlectron microscopy (cryo-EM) laboratory and Maastricht Instruments, a device for automated vitrification of very thin samples, the ‘Vitrobot’, was developed. The Vitrobot rapidly proved to be a fitting solution for vitrification and became the standard for sample preparation for cryo-EM after licensing it to FEI in 2002 (now ThermoFisher Scientific).
Today, the Division of Nanoscopy of the Maastricht MultiModal Molecular Imaging Institute (M4I) continues advancing structural biology by tackling tuberculosis and cancer. Led by Prof. dr. Peter Peters, both single particle analysis as well as electron tomography are applied to gain understanding of macromolecular nano-machinery inside human cells and their pathogens. The aim is applying this knowledge for the design of effective drugs and treatments for diseases that affect millions of people worldwide.
Since the development of the Vitrobot, the Division of Nanoscopy and engineers from Instrument Development, Engineering and Evaluation (IDEE) of Maastricht University have been developing the next generation technology and applications in cryo-workflows to study single particles, cells and organoids. This has resulted in the VitroJet.
Bart Beulen PhD
Prof. Peter Peters PhD
R&D Engineer & Inventor
Lead of Application Development
Senior System Engineer
Tom Van Osch
Manager Customer Service and Operations
M4I Research team, Maastricht University, the Netherlands
CryoSol cooperates with the M4I Division of Nanoscopy department of Maastricht University, headed by Prof. dr. Peter Peters. M4I Division of Nanoscopy strives for greater insight into the 3D structure of proteins in cells, paving the way for developing more effective treatments for diseases such as cancer and tuberculosis while gaining better understanding of how protein complexes manage healthy and diseased cells, allowing drugs, vaccines and treatments to work more effectively.
Careers, join us
As a young ambitious company, we are always open to discuss opportunities with highly skilled and motivated people in the field of cryo EM. See the vacancies below.
Feel free to send an open application via email firstname.lastname@example.org and specify ‘open application’ in the subject line. Please include your resume and motivational cover letter.
Strengthen the R&D team by contributing and leading projects to the further development of core competencies. Develop and execute protocols for appropriate testing, characterization and optimization of processesread more
Contribute to the further development of core competencies, strengthening the value propositions of CryoSol. Perform high level trouble shooting.read more